February 15, 2010 – PZP’s Reversibility

As we’ve gone over in previous posts, PZP is a vaccine. It influences immune responses that lead to the disruption of fertilization. PZP must be administered periodically as its ability to influence immune responses is reduced over time. Depending on the method of delivery, treatments must be given every one to two years at a minimum. But let’s think about the other side of all this: How many PZP treatments can a mare receive before her immune system has been so bolstered that she is unlikely to get pregnant again? That is, are PZP’s effects reversible? This will be the topic of today’s discussion.


Published in: on February 14, 2010 at 3:04 pm  Comments (12)